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 Mayim BialikMayim Bialik (formerly known as "Blossom") guest stars as herself. Mayim is Kirstie's neighbor who is quick to burst Kirstie's bubble as to who Gwen Stefani, another neighbor, is actually friends with. She later becomes intimate with Kirstie's Assistant Eddie. |
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 Mark CurryMark Curry guest stars as the network's head of development, Max Cooper, who appreciates Kirstie's bountiful booty! |
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 Carmen ElectraCarmen Electra guest stars as herself. Eddie thinks he has a future with Carmen while she sees it as more of a stalking situation. |
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 Larry KingLarry King guest stars as himself who airs revealing footage of Kirstie and her family on Larry King Live. |
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 Melissa GilbertMelissa Gilbert guest stars as herself. After a run-in with Eddie she gets his 411 while he mistakenly thinks it's a career opportunity. |
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 Merv GriffinMerv Griffin plays himself who Kirstie calls to help her find the perfect "well off" gentleman. Merv invites her to a party where he introduces her to the billionaire John. |
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 Geoffrey LewisGeoffrey Lewis guest stars as Kirstie's Dad who gets dragged into Kirstie and her crack addict brother Jimmy's argument over which one of them has an actual addiction and needs help. |
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 Christopher McDonaldChristopher McDonald guest stars as Kirstie's crack addict brother Jimmy who believes that if Kirstie smokes crack then she'll lose weight. |
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 Michael McDonaldMichael McDonald guest stars as Kirstie's agent Sam Raskal trying to get Kirstie the roles she demands. |
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 Kevin NealonKevin Nealon plays record producer Johnny Knightly, a neighbor of Kirstie's, who Kevyn tries to hook up with Kirstie. Mistaking Kevyn for a hooker, he invites her in. When Johnny later shows up at Kirstie's door to "party" she quickly snubs him. |
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 Rhea Perlman
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 Kelly PrestonKelly Preston guest stars as the holistic diet guru character, Quinn Taylor Scott, who advises Kirstie on the proper ways to diet. |
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 Leah ReminiLeah Remini guest stars as herself. Leah goes out of her way to apologize to Kirstie after making a public remark about Kirstie's weight. |
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 Kid RockKid Rock guest stars as himself. Finding themselves in the same place Kirstie and Kid Rock keep trying to get together for a little fun but things keep getting in the way. |
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 Wally ShawnWallace Shawn guest stars as Dr. Van Oy, who advises Kirstie that in order to lose weight all she has to do is surround herself with small things. |
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 Bill SmitrovichBill Smitrovich stars as John, a billionaire tycoon introduced to Kirstie by Merv Griffin. John becomes smitten with Kirstie and she with him. While appearing to be the perfect man in many areas for her he turns out to be a bit too emotional. |
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 Connie StevensConnie Stevens stars as Kirstie's Mom who gets dragged into Kirstie and her crack addict brother Jimmy's argument over which one of them has an actual addiction and needs help. |
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 John TravoltaJohn Travolta guest stars as himself, Kirstie's good friend who encourages her to pull herself together |
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 Jeff ZuckerNBC Chief Jeff Zucker guest stars as himself who agrees to see Kirstie so she can pitch a show idea. |
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