Hecate and Ethan struggle to survive the harsh wasteland of the New Mexico desert. Kaetenay reveals to Sir Malcolm the truth behind his connection to Ethan. Back in London, Frankenstein's addition to Jekyll's formula is a success.
"Penny Dreadful is trading the confines of Vanessa's padded cell for the expanse of the American Southwest this week, but it doesn't feel any less claustrophobic."
Ethan Chandler, Dr. Frankenstein, Dorian Gray, Sir Malcolm, the Creature, and Lily must each face their own monstrous selves. But for Vanessa Ives, accepting her demons could exact a terrible cost and plunge the world into darkness.
Vanessa Ives and her allies find themselves locked in epic battle against an unholy evil; Sir Malcolm falls under the spell of a bewitching temptress; Ethan's big secret becomes known as his past comes back to haunt him.
Vanessa Ives battles an evil demon determined to possess her; Sir Malcolm Murray tries to rescue his cursed daughter; Ethan Chandler becomes enmeshed with a group of vampire hunters and falls for a doomed local prostitute.