A manhunt ensues after Frank goes on a bender and turns up missing on Friday, the day he never fails to cash his disability check, and turns up in Toronto with no idea how he got there.
It’s last call and the Gallaghers are going out with the biggest bang ever. Changes are coming that will force each of them to either step up or hit the road, but they know one thing for certain – Gallaghers may grow up, but they’ll never grow apart.
Frank's exploits lead him to an old friend, Debbie rules over the Gallagher household with an iron fist, Lip navigates his relationship with Tami, and Gallavich returns as Ian and Mickey rekindle their relationship in prison as both cellmates and lovers.
Political fervor hits the South Side, and the Gallaghers take justice into their own hands. Frank sees financial opportunity in campaigning and Fiona tries to build on the success of her apartment building.
The Gallaghers are finally on an upswing! Frank tries to become a contributing member of society, Fiona finds success as a landlord, Lip struggles to stay sober, Ian takes up a cause, and Debbie tries life as a working single mom.
The Gallaghers have always been fiercely loyal to one another, but now that Frank has taken things too far will his outraged family finally declare war? One thing's for sure: there's never a dull moment for this clan.
The Gallaghers are finally getting their acts together and striking out on their own, but growing up could also mean growing apart. One thing's certain: nothing ever comes easy when your last name is Gallagher -- except trouble.
Fiona gets into a surprising love triangle; Frank falls for a dying doctor; Lip commits himself to college life and becomes romantically involved with a mentor; Ian and Mickey struggle to manage Ian's bi-polar disorder.
Fiona gets into legal trouble after a party goes horribly wrong; Frank battles liver disease; Lip struggles with the realities of college life; Ian forces Mickey to confront his sexuality.
Jimmy struggles to balance his relationship with Fiona and his obligations to Estefania; Frank alientates his children and then tries to win them back; Karen returns and drives a wedge between Lip and Mandy with dire consequences.
Frank and Monica rekindle their self-destructive relationship; Fiona is thrown when Steve arrives home with a surprise; Lip makes big changes; Karen and Sheila clash over Karen's new husband Jody.
Frank goes missing and turns up in Toronto, tries to embrace sobriety, and bends the law to protect his disability checks; Fiona falls for a player with a lot of money and a big secret; Ian embraces his sexuality.