Tara suffers from Dissociative Identity Disorder (DID), which results in the appearance of several eccentric alternate personalities at the most inopportune of times. Tara has recently gone off her medication in hopes of determining what happened to her to cause her condition. This means her alters appear more frequently than ever, and new alters are making their presence known. Juggling her condition with family and career means it's never a dull moment for Tara and her family.
Max is a hard working husband and father who will do anything for family and never knows what's waiting at home. He has stuck by Tara through thick and thin, but his commitment to never sleep with alters has been tested a few times.
Charmaine is Tara's sister who gets by with only one personality -- and really could use a little more attention. She's been on a quest for Mr. Right for far too long, which has landed her pregnant by one man and abandoned at the altar by another.
Marshall is a sensitive, good-natured kid who is coming to terms with his homosexuality. A crush on a straight boy ended in disaster, but his relationship with the school's cute gay activist seems to be getting more serious.
Kate is the Gregson's oldest, and she often bears the brunt of her mother's illness. A bit of a wild child, she rebels hard and often. Kate graduated from high school early and is now trying to figure out what she wants to be when she grows up.